Traditional Chinese medicine against COVID-19: Role of the intestinal microbiota

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Biomed Pharmacologist. 2022 Mar 8;149:112787. doi: 10.1016/j.biopha.2022.112787. Online ahead of print.


Coronavirus disease 2019 (COVID-19) is an acute respiratory infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and it has become a public health problem worldwide. In addition to respiratory symptoms, some COVID‑19 patients also experience various gastrointestinal symptoms and even consider gastrointestinal symptoms as the first manifestation. Abundant evidence has shown that SARS-CoV-2 infection can disrupt the gut microbiota balance and that gut microbiota disorders can worsen the condition of patients with COVID-19. Therefore, maintaining the balance of the gut microbiota should become a new potential therapeutic target for the treatment of COVID-19. Traditional Chinese Medicine (TCM) has significant effects in all stages of COVID-19 prevention and treatment. It can regulate the gut microbiota and is an ideal gut microecological regulator. This review summarizes the benefits and clinical efficacy of TCM in the treatment of COVID-19 and discusses the relationship between TCM and gut microbiota, the relationship between COVID-19 and gut microbiota, the mechanism of microbiota disorders intestinal infections induced by SARS-CoV-2, the relationship between cytokine storms and the gut microbiota, and the role and mechanism of TCM in the prevention and treatment of COVID-19 by regulating the gut microbiota to provide new research ideas for TCM in the prevention and treatment of COVID-19.

PMID:35279010 | DOI:10.1016/j.biopha.2022.112787

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